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Kronetrar reverserar p-glykoproteinmedierad
Du kan ställa in hur cookies skall lagras i inställningarna för din webbläsare. 2013-04-01 Krishnamurthy et al: Efflux transporters in the pathogenesis of hydrocephalus 367 www.cmj.hr Hydrocephalus is a common brain disorder that affects chil-dren and individuals of all ages. It is the most common con-genital abnormality in children (one out of 500 births) (1). If left untreated, hydrocephalus can lead to permanent brain Efflux cell membrane transporters are not only responsible for moving the parent drug and metabolites of some medications out of the cell, but may also contribute to drug resistance by diminishing the desired therapeutic or biologic effect.2 As such, anything that prevents or inhibits a medication from being transported out of certain cells could result in excessive blood concentrations of the efflux transporters: Abbreviation Variation Long Form Variation Pair(Abbreviation/Long Form) Variation No. Year Title Co-occurring Abbreviation; 1 : 2019: An update on polyphenol disposition via coupled metabolic pathways. DMEs, NRs, PBPK, SAR: 2 : 2018: A systematic review of Efflux transporters are positioned so as to encounter potentially harmful substances face-to-face — in important places like the intestine, the placenta, and the blood-brain and blood-testes barriers, making them an excellent first line of defense. Embedded within a cell’s membrane, this protein 2013-01-01 transportör består av vardera två TMD och två NBD domäner.
von lateinisch: effluere - ausfließen, auslaufen. Definition. Mit dem Begriff Efflux bezeichnet man den Ausstrom von Ionen oder Molekülen aus der Zelle Krishnamurthy et al: Efflux transporters in the pathogenesis of hydrocephalus 367 www.cmj.hr Hydrocephalus is a common brain disorder that affects chil-dren and individuals of all ages. It is the most common con-genital abnormality in children (one out of 500 births) (1). If left untreated, hydrocephalus can lead to permanent brain d’efflux Composés endogènes ou exogènes variés Défense de l’organisme Diversité des transporteurs Blood pH=7.2 CNT PepT1 OATP MRP3 MRP1 OCT P-gp BCRP MRP2. Viele übersetzte Beispielsätze mit "efflux transporter" – Deutsch-Englisch Wörterbuch und Suchmaschine für Millionen von Deutsch-Übersetzungen. CYP 3A4 hämning genom tipranavir/r och P-gp (en efflux transportör i tarmen) hämning genom klaritromycin.
Prevymis letermovir Läkemedelsverket / Swedish Medical
Authors: Iman A. Elkiweri, Ph.D, Efflux transporter inhibition or substrate assay Measurement Service Stably transfected efflux transporter expressing cells or membrane vesicles are used to study whether a test drug is an inhibitor or substrate of an efflux transporter, e.g.: MDR1, BCRP or BSEP. Enligt EU-lag vill vi informera dig om att vår webbplats använder cookies med syfte att ge dig en upplevelse av högsta kvalitet. Du kan ställa in hur cookies skall lagras i inställningarna för din webbläsare.
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The major efflux transporters of the ABC family include MDR1 (P-glycoprotein,P-gp, ABCB1), BCRP (ABCG2), and MRP2 (ABCC2). The ABC efflux transporter P-glycoprotein (Pgp) has been demonstrated as a key element of the BBB that can actively transport a huge variety of lipophilic drugs out of the brain capillary endothelial cells that form the BBB. P-gp is an efflux protein system associated with the ATP binding cassette (ABC) sub-family B membrane or Multi-drug resistance 1 (MDR1) or cluster of differentiation 243 which belong to ABCB (MDR) super family of ABC transporter [ 6 ]. Efflux transporter-expressing cells actively pump substrates out of the cell, which results in a lower rate of substrate accumulation, lower intracellular concentration at steady state, or a faster rate of substrate elimination from cells loaded with the substrate. A comprehensive in vitro ABC (efflux) transporter assay portfolio is available as contract research service. Ciprofloxacin is subject to efflux from J774 macrophages through a multidrug resistance-related protein-like transporter (J. M. Michot, F. Van Bambeke, M. P. Mingeot-Leclercq, and P. M. Tulkens, Antimicrob. Efflux transport proteins (transporters) provide a potential solution to facilitate the export of these products, mitigate toxic effects, and enhance production.
ABC-transportörer delas in i två grupper baserat på förmågan att antingen kunna föra substrat in (influx) eller ut (efflux) ur olika celler.
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Det är därför angeläget att på sikt finna hållbara lösningar för att hantera den allt mer växande resistensproblematiken. Efflux mediated multidrug resistance (MDR) is a major problem in the treatment of bacterial, fungal and protozoal infections in addition to cancer chemotherapy.
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(13) The efflux rate for EB of strains with duplicated ebr genes was twice the rate of strains with a single ebr gene.
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Learn vocabulary, terms, and more with flashcards, games, and other study tools. Contextual translation of "effluxtransportörerna" into English. Human translations with examples: rifabutin therapy. og efflux-transport i lever og tarm.